Dr. Hegeman is scientific researcher at Human and Animal Physiology (HAP), Wageningen University, the Netherlands. HAP has extensive expertise in performing controlled dietary intervention studies to improve diet-and age-related metabolic healths problems. These dietary intervention studies are performed in humans, animals and/or cells. HAP is particularly recognized for the physiological, metabolic, functional genomic, biochemical/molecular and histological analysis of such studies. The research of Dr. Hegeman is focussed on the effects of nutritional intervention strategies on the balance of reactive oxygen species and antioxidant defence systems in situations of metabolic health and decline.